Miss Emilie Kimmins, who established Kimmins school in 1898, was a member of the Zenana Bible and Medical Missionary Fellowship, and it was while she was working as Principal of Queen Mary School in Bombay that she became deeply concerned for the education of the European and Anglo Indian children who needed to leave Bombay because of their health problems. Her answer was to offer these children a good education in the healthy climate of Panchgani.
She remained at the school until 1921, and made such an outstanding contribution to the Hill Station and to the schools in Panchgani that she has been referred to as the "Queen of Panchgani". She not only laid the foundations of the buildings of her school but also of its educational and moral standards.

The central buildings of both the school and the hostel reflect the inspiration and dedication of Miss Kimmins. They are among the most attractive buildings in Panchgani, with a charm rarely equaled today, yet they have proved strong and are able to adapt to the requirements of the twenty-first century. Miss Kimmins was interested in the well being of each child in the school, helping to develop each one of them to their maximum potential.

Miss Pearsall followed Miss Kimmins as Principal, and the school was fortunate again to have a long serving leader. She took over in 1921, and finally left the school in 1948, with a break of several years during this time. During her tenure electricity was first switched on and running water was made available to the renovated bathrooms. She was described as "encircling with love other women's children", and many remember her with deep affection and gratitude. During her years the academic emphasis of the school developed, music became an important part of the curriculum, and the school began to meet the needs of the students of Independent India.

Following some difficulties in 1949, it was contemplated to close the school, but many believed that there was a need for a school with its traditions for building modern India. This confidence motivated the next generation of leaders to adapt to changes and to overcome problems, so that the school grew from strength to strength.

Miss Yelland, who was Principal from 1952 until 1969 worked hard to keep the school going. Although many of the European and Anglo Indian children left the school, there was a steady increase in the number of Indian children benefiting from the education offered. These students came from within India and from Indian communities settled all over the world. For several years the school also received a group of Tibetan children. When the school celebrated its Centenary in 1998 a large number of past students from many countries came to meet their friends.

In the early days most of the teaching staff were British, but later the school began to employ well qualified Indian teachers. Miss Yelland was followed as Principal by Miss Gilbert from 1969 until 1979, and she was followed by the first Indian Principal, Miss Fahmidah Inayat from 1979 to 1994.
The curriculum of the school has changed steadily providing education relevant for all round development of girls to meet the changing needs of the Indian society.
In 1974, the Management of the school passed to the Christian Medical and Educational Fellowship Trust, based in Bombay.
The Trust has added new buildings including a large multi purpose building housing the library and dining room, and older ones have been renovated.

Through these changes the school seeks to remain true to the vision of its founder, providing first class education and individual care for girls to meet the challenges of the twenty-first century, in the context of the teachings of Jesus Christ.